{"id":2016,"date":"2026-04-09T16:04:28","date_gmt":"2026-04-09T14:04:28","guid":{"rendered":""},"modified":"2026-04-09T16:04:28","modified_gmt":"2026-04-09T14:04:28","slug":"friday-seminar-sylvie-lorthois","status":"publish","type":"buni_events","link":"https:\/\/incia.u-bordeaux.fr\/fr\/events\/friday-seminar-sylvie-lorthois\/","title":{"rendered":"Friday Seminar &#8211; Sylvie Lorthois"},"content":{"rendered":"<p><strong>Venue: Centre Broca<\/strong><\/p>\n<hr \/>\n<p><strong><a href=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/10\/lorthois.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-196561\" src=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2025\/10\/lorthois.png\" alt=\"\" width=\"203\" height=\"203\" \/><\/a>Sylvie Lorthois<br \/>\n<\/strong>Directrice de Recherche CNRS<br \/>\nPorous and Biological Media Group &#8211; Institut de M\u00e9canique des Fluides de Toulouse<br \/>\n<a href=\"https:\/\/www.imft.fr\/pages-personnelles\/lorthois-sylvie\/\">www.imft.fr\/<\/a><\/p>\n<p>Invited by Jean-Luc Morel (INCIA)<\/p>\n<h3>Title<\/h3>\n<p>In silico modeling of brain microvascular function to highlight the overlap between cerebrovascular and Alzheimer\u2019s Disease.<\/p>\n<h3>Abstract<\/h3>\n<p>The cerebral microvascular system is essential to a large variety of physiological processes in the brain, including blood delivery, neurotoxic waste clearance and blood flow regulation as a function of neuronal activity (neuro-vascular coupling). It also plays a major role in disease (stroke, neurodegenerative diseases, \u2026). However, the functional consequences of vascular damage (including acute occlusions or long-term remodeling in ageing or disease) are poorly understood.<\/p>\n<p>In this context, in silico modeling approaches are increasingly important, and enable to integrate the specific multi-scale architecture of the brain microvascular network with the physics of blood flow in confined conditions. I will discuss how the resulting scaling-laws for blood flow and molecular transport are mostly driven by the topology of the microvascular network, deterministically leading to the emergence of hypoxic pockets in sub-cortical regions under mild hypoperfusion. I will highlight how these results help understand the overlap between cerebrovascular and Alzheimer\u2019s Disease.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In silico modeling of brain microvascular function to highlight the overlap between cerebrovascular and Alzheimer\u2019s Disease. \/\/ Venue: Centre Broca<\/p>\n","protected":false},"template":"","categories":[],"class_list":["post-2016","buni_events","type-buni_events","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/buni_events\/2016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/buni_events"}],"about":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/types\/buni_events"}],"wp:attachment":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/media?parent=2016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/categories?post=2016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}