{"id":2034,"date":"2026-05-12T09:38:24","date_gmt":"2026-05-12T07:38:24","guid":{"rendered":"https:\/\/incia.u-bordeaux.fr\/?post_type=buni_events&#038;p=2034"},"modified":"2026-05-12T09:40:14","modified_gmt":"2026-05-12T07:40:14","slug":"seminaire-megan-fox","status":"publish","type":"buni_events","link":"https:\/\/incia.u-bordeaux.fr\/fr\/events\/seminaire-megan-fox\/","title":{"rendered":"S\u00e9minaire \u2013 Megan Fox"},"content":{"rendered":"\n<p><strong>Lundi 11 Mai \/ 11:30<\/strong><\/p>\n\n\n\n<p><strong>Lieu: Centre Broca<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright\"><a href=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2026\/02\/fox_headshot.jpg\"><img decoding=\"async\" src=\"https:\/\/cdn-neurocampus.onlc.eu\/wp-content\/uploads\/2026\/02\/fox_headshot-360x360.jpg\" alt=\"\" class=\"wp-image-197434\"\/><\/a><\/figure><\/div>\n\n\n<p><strong><a href=\"https:\/\/med.psu.edu\/departments-faculty\/directory\/megan-fox\">Megan E Fox, PhD.<\/a><\/strong><br>Assistant Professor and Garfield B. Russell Career Development Professor in Medical Education<br>Department of Anesthesiology,<br>Department of Neuroscience and Experimental Therapeutics,<br>Penn State College of Medicine<br><a href=\"https:\/\/www.psu.edu\/copyright-information\">Pennsylvania State University<\/a><\/p>\n\n\n\n<p>Invit\u00e9e par Michel Engeln (INCIA)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Titre (EN)<\/h3>\n\n\n\n<p>Molecular mechanisms underlying risk and resilience to opioid seeking<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Abstract (EN)<\/h3>\n\n\n\n<p>The neurobiological mechanisms that confer vulnerability or resilience to opioid use disorder remain incompletely understood. Our work examines how individual differences in circuit function and stress sensitivity shape opioid seeking and relapse-like behavior, integrating molecular, circuit-based, and behavioral approaches in mice. Recent findings from our lab reveal that alterations in dopamine D1 receptor\u2013expressing medium spiny neurons can profoundly influence fentanyl seeking without broadly disrupting reward learning or drug intake. These differences are accompanied by changes in dopamine receptor signaling, gene expression, dendritic complexity, and circuit function. Ongoing work extends these observations to show that stress exposure and stress susceptibility interact with mesolimbic circuitry to further influence opioid-related behaviors, highlighting stress as a key modulator of individual risk and resilience.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lundi 11 Mai \/ 11:30 Lieu: Centre Broca Megan E Fox, PhD.Assistant Professor and Garfield B. Russell Career Development Professor [&hellip;]<\/p>\n","protected":false},"template":"","categories":[],"class_list":["post-2034","buni_events","type-buni_events","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/buni_events\/2034","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/buni_events"}],"about":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/types\/buni_events"}],"wp:attachment":[{"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/media?parent=2034"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/incia.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/categories?post=2034"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}