Early intrinsic excitability plasticity of neocortical engram neurons defines memory formation and precision
Senka Hadzibegovic, Liangying Zhu, Melanie Ginger, Maria Gueidão Costa, Paula Alvarez Menendez, Rafaël De Sa, Katy Le Corf, Yves Le Feuvre, Olivier Nicole, Bruno Bontempi, Andreas Frick
Nature Communications. 2025-12-05
10.1038/s41467-025-66975-3

A novel Y-maze paradigm with enhanced sensitivity to subtle spatial recognition memory impairments in mice
Senka Hadzibegovic, Bruno Bontempi, Olivier Nicole
BMC Methods. 2025-10-01
10.1186/s44330-025-00043-6

Normal and slow learners: a new discriminative method based on the speed of spatial learning in aged mice
Céline Duffau, Senka Hadzibegovic, Vojislav Andelkovic, Bruno Bontempi, Olivier Nicole
Front. Aging Neurosci.. 2025-06-06
10.3389/fnagi.2025.1567929

Examining the effects of extremely low-frequency magnetic fields on cognitive functions and functional brain markers in aged mice.
Senka Hadzibegovic, Olivier Nicole, Vojislav Andelkovic, Florence Poulletier de Gannes, Annabelle Hurtier, Isabelle Lagroye, Bruno Bontempi
Sci Rep. 2025-03-11
10.1038/s41598-025-93230-y

Investigating the Impact of NMDA Receptor Organization and Biological Sex in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
Senka Hadzibegovic, Bruno Bontempi, Olivier Nicole
IJMS. 2025-02-18
10.3390/ijms26041737

Therapeutic efficacy of the BKCa channel opener chlorzoxazone in a mouse model of Fragile X syndrome
Celeste Ferraguto, Marion Piquemal-Lagoueillat, Valerie Lemaire, Maïté M. Moreau, Stefania Trazzi, Beatrice Uguagliati, Elisabetta Ciani, Sandrine S. Bertrand, Eric Louette, Bruno Bontempi, Susanna Pietropaolo
Neuropsychopharmacol.. 2024-09-02
10.1038/s41386-024-01956-6

Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex
Benjamin Bessières, Julien Dupuis, Laurent Groc, Bruno Bontempi, Olivier Nicole
Sci. Adv.. 2024-08-30
10.1126/sciadv.ado1148

Physical exercise restores adult neurogenesis deficits induced by simulated microgravity
Alexandra Gros, Fandilla Marie Furlan, Vanessa Rouglan, Alexandre Favereaux, Bruno Bontempi, Jean-Luc Morel
npj Microgravity volume. 2024-06-21
10.1038/s41526-024-00411-6

Early Administration of the Phytocannabinoid Cannabidivarin Prevents the Neurobehavioral Abnormalities Associated with the Fmr1-KO Mouse Model of Fragile X Syndrome
Marika Premoli, William Fyke, Luigi Bellocchio, Valerie Lemaire, Marie Wolley-Roberts, Bruno Bontempi, Susanna Pietropaolo
Cells. 2023-07-25
10.3390/cells12151927

Targeting Pdzrn3 maintains adult blood-brain barrier and central nervous system homeostasis
Florian Gueniot, Sebastien Rubin, Pauline Bougaran, Alice Abelanet, Jean Luc Morel, Bruno Bontempi, Carole Proust, Pascale Dufourcq, Thierry Couffinhal, Cecile Duplàa
J Cereb Blood Flow Metab. 2021-10-13
10.1177/0271678X211048981

Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice
Eléonore Bertin, Thomas Deluc, Kjara S. Pilch, Audrey Martinez, Johan-Till Pougnet, Evelyne Doudnikoff, Anne-Emilie Allain, Philine Bergmann, Marion Russeau, Estelle Toulmé, Erwan Bezard, Friedrich Koch-Nolte, Philippe Séguéla, Sabine Lévi, Bruno Bontempi, François Georges, Sandrine S. Bertrand, Olivier Nicole, Eric Boué-Grabot
Mol Psychiatry. 2020-01-08
10.1038/s41380-019-0641-8

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.
David Castonguay, Julien Dufort-Gervais, Caroline Ménard, Manavi Chatterjee, Rémi Quirion, Bruno Bontempi, Jay S. Schneider, Amy F.T. Arnsten, Angus C. Nairn, Christopher M. Norris, Guylaine Ferland, Erwan Bézard, Pierrette Gaudreau, Paul J. Lombroso, Jonathan Brouillette
Current Biology. 2018-04-01
10.1016/j.cub.2018.02.047

Assessing recent and remote associative olfactory memory in rats using the social transmission of food preference paradigm
Benjamin Bessières, Olivier Nicole, Bruno Bontempi
Nat Protoc. 2017-06-22
10.1038/nprot.2017.050

Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation
Olivier Nicole, Senka Hadzibegovic, Judyta Gajda, Bruno Bontempi, Tiaza Bem, Pierre Meyrand
Sci Rep. 2016-03-07
10.1038/srep22728

Reduced cytochrome oxidase activity in the retrosplenial cortex after lesions to the anterior thalamic nuclei.
Magdalena Mendez-Lopez, Jorge L. Arias, Bruno Bontempi, Mathieu Wolff
Behavioural Brain Research. 2013-08-01
10.1016/j.bbr.2013.04.052

Tiny light, big hope
Benjamin Bessieres, Bruno Bontempi, Olivier Nicole
Mov Disord.. 2013-08-01
10.1002/mds.25530

Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity
F. El Gaamouch, A. Buisson, O. Moustie, M. Lemieux, S. Labrecque, B. Bontempi, P. De Koninck, O. Nicole
Journal of Neuroscience. 2012-08-01
10.1523/JNEUROSCI.5622-11.2012

Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory
Edith Lesburguères, Oliviero L. Gobbo, Stéphanie Alaux-Cantin, Anne Hambucken, Pierre Trifilieff, Bruno Bontempi
Science. 2011-02-18
10.1126/science.1196164

Early tagging of cortical networks is required for the formation of enduring associative memory.
E. Lesburgueres, O. L. Gobbo, S. Alaux-Cantin, A. Hambucken, P. Trifilieff, B. Bontempi
Science. 2011-02-17
10.1126/science.1196164

The Intralaminar Thalamic Nuclei Contribute to Remote Spatial Memory
J. Lopez, M. Wolff, L. Lecourtier, B. Cosquer, B. Bontempi, J. Dalrymple-Alford, J.-C. Cassel
Journal of Neuroscience. 2009-03-11
10.1523/jneurosci.5576-08.2009